- Title
- Helicobacter pylori and other factors in recurrent aphthous stomatitis: A cross-sectional study
- Creator
- Mazzoleni, Daniel Schebela; Mazzoleni, Felipe; Talley, Nicholas Joseph; Mazzoleni, Luiz Edmundo; Francesconi, Carlos Fernando de Magalhães; Milbradt, Tobias Cancian; Uchoa, Diego Mendonca; Birnfeld, Heitor Ribeiro; Andrighetto, Luiza Vitelo; Ries, Sacha Allebrandt da Silva; Simon, Daniel
- Relation
- Oral Diseases Vol. 28, Issue 2, p. 390-397
- Publisher Link
- http://dx.doi.org/10.1111/odi.13765
- Publisher
- Wiley-Blackwell
- Resource Type
- journal article
- Date
- 2022
- Description
- Objectives: To evaluate the role of Helicobacter pylori and other risk factors in recurrent aphthous stomatitis (RAS). Methods: Patients with functional dyspepsia responded to questionnaires regarding demographic and clinical data, anxiety and depression, and a specific RAS questionnaire. They underwent upper digestive endoscopy and H. pylori evaluation. Results: 476 patients were included and of the 372 evaluated for H. pylori, 65.6% were H. pylori-positive. RAS was reported by 32.6% (155/476). In the bivariate analysis of the 372 patients evaluated for gastric H. pylori status, positive subjects had a lower RAS prevalence (29.9%; 73/244) than H. pylori-negative (41.4%; 53/128) (p = .026). Smoking (p = .005) and older age (p = .034) were also associated with a lower prevalence, while female gender (p = .032) and lower income (p = .046) presented higher RAS prevalence. In the multivariate analysis, H. pylori infection (p = .017), smoking (p = .001), and older age (p = .013) were protective factors, while lower income (p = .030) and anxiety (p = .042) were risk factors. In the multivariate analysis of all patients, female gender, lower income, and more schooling years were risk factors. Conclusions: An unexpected lower prevalence of RAS was found in H. pylori-positive patients. Smoking, sex, age, income, education, and anxiety were associated with RAS.
- Subject
- age groups; anxiety; dyspepsia; educational status; income; risk factors
- Identifier
- http://hdl.handle.net/1959.13/1452730
- Identifier
- uon:44503
- Identifier
- ISSN:1354-523X
- Language
- eng
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